Dual Targeting EGFR and STAT3 With Erlotinib and Alantolactone Co-Loaded PLGA Nanoparticles for Pancreatic Cancer Treatment

Pancreatic cancer (PC) is one of the most common malignancies and also a leading cause of cancer-related mortality worldwide.Many studies have shown that epidermal growth Raw Seaweeds factor receptor (EGFR) is highly expressed in PC, which provides a potential target for PC treatment.However, EGFR inhibitors use alone was proven ineffective in clin

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Optogenetic mimicry of the transient activation of dopamine neurons by natural reward is sufficient for operant reinforcement.

Activation of dopamine receptors in forebrain regions, for minutes or longer, is known to be sufficient for positive reinforcement of stimuli and actions.However, the firing rate of dopamine neurons is increased for only about 200 milliseconds following Jurassic Park natural reward events that are better than expected, a response which has been des

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The Pap smear screening as an occasion for smoking cessation and physical activity counselling: effectiveness of the SPRINT randomized controlled trial

Abstract Background The organized Cervical Cancer Screening Programme (CCSP) in Italy might represent an occasion to deliver smoking cessation (SC) counselling to women attending the Pap test examination.Evidence of effectiveness of physical activity (PA) promotion and intervention in adjunct to SC counselling is not strong.Objective of the SPRINT

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